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PFIZER REPORTS FOURTH- QUARTER AND FULL- YEAR 2. RESULTS . The Innovative Products business is composed of two operating. Global Innovative Pharmaceutical segment (GIP)(4). Who can apply Applying for refills or additional medications Pf iz erp scto nm d available through the Connection to Care Program What you need to send us Pfizer Connection to Care application Accupril I certify and attest that if I receive medicine(s) provided by Pfizer through the Connection to Care program: Global Vaccines, Oncology and Consumer Healthcare. VOC)(4). The Established Products business. Global Established Pharmaceutical segment (GEP)(4). Hospira commercial operations. Financial. results for each of these segments are presented in the Operating. Segment Information section. All. percentages have been calculated using unrounded amounts. Results for. fourth- quarter and full- year 2. For 2. 01. 6, the. Venezuela and excludes any impact from the pending. Allergan plc (Allergan). I am. particularly pleased with the performance of our Prevnar 1. Ibrance launches in the U. S. In addition, Eliquis, Xeljanz and the. Hospira portfolio, among other assets, along with operational growth in. Read continued, “The integration of Hospira is well underway and we. Allergan, which we. We see this. transaction as a very effective driver of accelerating the. Innovative business, strengthening our. Established business and more efficiently allocating our capital. In addition to our strong financial. Hospira acquisition, announced the pending. Allergan and continued to deliver shareholder value. Regarding our financial performance. EPS(2) despite an operating environment that remains. Importantly, Pfizer- standalone revenues increased 3%. Pfizer's first year of operational revenue growth. We. believe the completion of the Hospira acquisition and the pending. Allergan combination will strengthen our core businesses and better. Company for sustainable revenue growth in the future. Pfizer Inc Connection to Care Patient Assistance Program P.O. Louis, MO 63166-6585 1-(866. Lower income patients who have insurance coverage for prescription medicines may still be eligible for assistance through the Pfizer Connection. Compensation & Benefits Pfizer offers competitive compensation and benefits based on a variety of factors including prior experience. Depending on local custom and practice, Pfizer offers colleagues several benefits to help them meet their financial goals. Our guidance. for reported revenues(1) reflects anticipated. U. S. Our 2. 01. 6 financial guidance excludes any impact from the. Program Details PFIZER, INC. Pfizer RxPathways Lyrica (pregabalin) CONTACT. Re-orders can be placed by the HCP online via www.PfizerPAP.com, or through Pfizer RxPathways automated phone re-ordering system at 855-742-7497 For help with Prevnar.Allergan. Finally, our guidance for reported(1). EPS also reflects anticipated share. These planned repurchases are expected to more than offset the. Mr. Excluding the impact of legacy Hospira. Baxter International Inc. In emerging markets. Hospira operations, which contributed $7. Prevenar 1. 3 and certain other products. Emerging markets revenues were flat operationally. Hospira operations and continued. China offset by declines in certain Middle East. This decline was primarily due. Full- Year 2. 01. Reported revenues(1) decreased $7. This. decline was primarily due to a favorable change in the jurisdictional. Internal Revenue Service; and. Branded Prescription Drug Fee incurred in third- quarter 2. The subanalysis demonstrated Eliquis. VTE) and VTE- related death with significantly. The results of the subanalyses at each. AMPLIFY trial at six months. The new. data, including four oral presentations, contribute to the BMS and. Pfizer Alliance’s research in nonvalvular atrial fibrillation and. VTE in patients treated with Eliquis. Abstracts included new data. Phase 3 study, ARISTOTLE, as well as a. Food and Drug Administration (FDA) has accepted for. Priority Review for a supplemental New Drug. Application (s. NDA) for Ibrance. If approved, the s. NDA would expand the. Ibrance to reflect findings from the Phase 3 PALOMA- 3. Ibrance in combination with fulvestrant versus. The Prescription Drug User Fee. Act (PDUFA) goal date for a decision by the FDA is April 2. The study did not meet its primary efficacy. The study was conducted as a 1. The primary efficacy. The safety. profile observed in this study was consistent with that known for. The most common adverse events with pregabalin in this. There is. currently no treatment approved by the FDA for post- traumatic. If approved, Xalkori. FDA- approved biomarker- driven therapy for the. ROS1- positive metastatic NSCLC. Xalkori is currently. U. S. The PDUFA goal date for a decision by the. FDA is April 2. 01. In this study, Xalkori was used as the first. ALK- positive NSCLC. No. unexpected adverse events were observed. Efficacy and safety data. PROFILE 1. 02. 9 will be submitted for presentation at a future. The new data continue to characterize the safety and efficacy. Xeljanz in the treatment of RA. The delay is not. ALO- 0. 2 NDA, and no additional data. FDA. Pfizer is. continuing discussions with the FDA to finalize the label. Pfizer. cannot speculate on timing for the FDA decision. The JAVELIN Ovarian 2. Phase 3 study of a PD- L1 inhibitor investigated in this. An official. decision by the EC was granted in December 2. The SPIRE- SI study evaluated the. A total of 1. 84 patients. The trial met its primary endpoint. LDL- C level at 1. Complete study results of the SPIRE- SI trial will be. Results from other Phase. LDL- C reduction are expected throughout 2. Andexanet alfa, which is in Phase 3 clinical. U. S. The first four investments of the newly focused initiative. Conditionally Active. Biologics, immuno- oncology, neurodegenerative technologies and gene. Additional opportunities will continue to be identified by. Pfizer’s scientific leadership through their active involvement, and. Pfizer will help recipient companies fully explore their platforms in. This is an exclusive agreement between the Merck KGa. A- Pfizer. alliance and Syndax to study the combination of these two. Syndax will be responsible. Phase 1b/2 clinical trial. This represents an increase of 7% in. In November 2. 01. Pfizer announced that, consistent with 2. As of December 3. Pfizer had $1. 6. Allergan. shareholders will receive 1. Allergan shares by virtue of a share split, and Pfizer. Pfizer shares or to receive. Pfizer shares, provided that the aggregate amount of cash to be. In the event that elections to receive cash and. The completion of the transaction, which is. U. S. The merger agreement also provides. Pfizer and Allergan will be combined under the. Allergan entity, which, subject to approval by Allergan. Pfizer plc.”. In response to the ongoing challenges patients face in paying their. Pfizer announced. November 2. 01. 5 that it has doubled the allowable income level for. Pfizer medicines for free. With. this change, more than 4. Federal Poverty Level adjusted for family size ($4. Through the Pfizer. Rx. Pathways program, Pfizer offers patients, including those with. Pfizer medicines. From 2. 01. 0 to 2. Pfizer. has helped nearly 2. Pfizer prescriptions, making it the. Reported net income. Pfizer Inc. Reported diluted earnings per share (EPS) is defined. EPS attributable to Pfizer Inc. GAAP net income(1) and its. EPS(1) excluding. Adjusted. revenue, Adjusted cost of sales, Adjusted selling, informational. SI& A) expenses, Adjusted research and. R& D) expenses and Adjusted other (income)/deductions. Adjusted income measure. As. described under Adjusted income in the Management’s Discussion and. Analysis of Financial Condition and Results of Operations section. Pfizer’s Quarterly Report on Form 1. Q for the fiscal quarter. September 2. 7, 2. Adjusted income, among. We believe that investors’. See the accompanying reconciliations of certain GAAP. Reported to non- GAAP Adjusted information for the fourth quarter. Adjusted income and Adjusted. EPS to full- year 2. Reported net income(1). Reported diluted EPS(1). The Adjusted income and. Adjusted diluted EPS measures are not, and. U. S. GAAP net income and. EPS. 2. 01. 6. financial guidance excludes any impact from the pending combination. Allergan. The transaction is expected to close during the second. We assume no obligation. You can identify these statements by the fact. Among the factors. FDA and regulatory authorities in certain. Medicare, Medicaid or other publicly funded or subsidized. U. S. These. studies typically are part of a larger body of clinical data relating to. In addition. clinical trial data are subject to differing interpretations, and, even. Ireland (as amended from time to time) or the Prospectus. Rules issued by the Central Bank of Ireland pursuant to section 1. Act, and the Central Bank of Ireland (“CBI”) has not approved. Securities and Exchange Commission (the “SEC”) a registration. Form S- 4 that will include a Joint Proxy Statement of. Pfizer and Allergan that also constitutes a Prospectus of Allergan (the. Joint Proxy Statement/Prospectus”). Pfizer and Allergan plan to mail to. Joint Proxy. Statement/Prospectus in connection with the transaction. INVESTORS AND. SECURITY HOLDERS OF PFIZER AND ALLERGAN ARE URGED TO READ THE JOINT. PROXY STATEMENT/PROSPECTUS AND OTHER RELEVANT DOCUMENTS FILED OR TO BE. FILED WITH THE SEC CAREFULLY WHEN THEY BECOME AVAILABLE BECAUSE THEY. WILL CONTAIN IMPORTANT INFORMATION ABOUT PFIZER, ALLERGAN, THE. TRANSACTION AND RELATED MATTERS. Investors and security holders will be. Joint Proxy Statement/Prospectus (when. SEC by Pfizer and Allergan. SEC at www. sec. gov. Information regarding. Allergan’s directors and executive officers is contained in Allergan’s. SEC on April 2. 4, 2. Allergan’s Current. Reports on Form 8- K. To the best of the knowledge and belief. Pfizer (who have taken all reasonable care to ensure. Pfizer - Wikipedia, the free encyclopedia. Pfizer Inc. It is among the world's largest pharmaceutical companies. Pfizer's products include the blockbuster drug Lipitor (atorvastatin), used to lower LDL blood cholesterol; Lyrica (pregabalin) for neuropathic pain/fibromyalgia; Diflucan (fluconazole), an oral antifungal medication; Zithromax (azithromycin), an antibiotic; Viagra (sildenafil) for erectile dysfunction; and Celebrex/Celebra (celecoxib), an anti- inflammatory drug. Pfizer was founded in 1. Charles Pfizer and Charles F. Erhart in New York City as a manufacturer of fine chemicals. Its discovery of Terramycin (oxytetracycline) in 1. Pfizer has made numerous acquisitions, including Warner. Originally from Ludwigsburg, Germany, they launched a chemicals business, Charles Pfizer and Company, from a building at the intersection of Harrison Avenue and Bartlett Street. There, they produced an antiparasitic called santonin. This was an immediate success, although it was the production of citric acid that really kick- started Pfizer's growth in the 1. Pfizer continued to buy property to expand its lab and factory on the block bounded by Bartlett Street; Harrison Avenue; Gerry Street; and Flushing Avenue. Pfizer's original administrative headquarters was at 8. Maiden Lane in Manhattan. Pfizer chemists learned of a fungus that ferments sugar to citric acid and were able to commercialize production of citric acid from this source in 1. As a result, Pfizer developed expertise in fermentation technology. These skills were applied to the mass production of the antibioticpenicillin during World War II in response to the need of the U. S. As a result, Pfizer searched for new antibiotics with greater profit potential. Pfizer's discovery and commercialization of Terramycin (oxytetracycline) in 1. To augment its research in fermentation technology, Pfizer developed a drug discovery program focusing on in vitro synthesis. Pfizer also established an animal health division in 1. Terre Haute, Indiana. By the 1. 95. 0s, Pfizer had established offices in Belgium, Brazil, Canada, Cuba, Mexico, Panama, Puerto Rico, and the United Kingdom. In 1. 96. 0, the company moved its medical research laboratory operations out of New York City to a new facility in Groton, Connecticut. In 1. 98. 0 Pfizer launched Feldene (piroxicam), a prescription anti- inflammatory medication that became Pfizer's first product to reach one billion United States dollars in total sales. During a Phase III clinical trial involving 1. Lipitor versus Lipitor alone. Lipitor alone was not implicated in the results, but Pfizer lost nearly $1 billion developing the failed drug and the market value of the company plummeted afterwards. Food and Drug Administration (FDA), and agreed to a $2. Pfizer has hired customs and narcotics experts from all over the globe to track down fakes and assemble evidence that can be used to pursue civil suits for trademark infringement. Since 2. 00. 7, Pfizer has spent $3. Inventing a tablet- coating process gained Warner a place in the Smithsonian Institution. The merger was again driven in part by the desire to acquire full rights to a product, this time Celebrex (celecoxib), the COX- 2 selective inhibitor previously jointly marketed by Searle (acquired by Pharmacia) and Pfizer. In the ensuing years, Pfizer carried out a massive restructuring that resulted in numerous site closures and the loss of jobs including Terre Haute, Indiana; Holland, Michigan; Groton, Connecticut; Brooklyn, New York; Sandwich, England; and Puerto Rico. Pharmacia had been formed by a series of mergers and acquisitions from its predecessors, including Searle, Upjohn and SUGEN. Searle was founded in Omaha, Nebraska, in April 1. The founder was Gideon Daniel Searle. In 1. 90. 8, the company was incorporated in Chicago, Illinois. In 1. 94. 1, the company established headquarters in Skokie, Illinois. It was acquired by the Monsanto Company, headquartered in St. Louis, Missouri, in 1. The Upjohn Company was a pharmaceutical manufacturing firm founded in 1. Kalamazoo, Michigan, by Dr. Upjohn, an 1. 87. University of Michigan medical school. The company was originally formed to make friable pills, which were specifically designed to be easily digested. Greenstone was founded in 1. Upjohn as a generics division. Pharmacia was created in April 2. Pharmacia & Upjohn with the Monsanto Company and its G. D. The merged company was based in Peapack, New Jersey. The agricultural division was spun off from Pharmacia, as Monsanto, in preparation for the close of the acquisition by Pfizer. The company pioneered the use of ATP- mimetic small molecules to block signal transduction. After the Pfizer merger, the SUGEN site was shut down in 2. Pfizer. These included sunitinib (Sutent), which was approved for human use by the FDA in January 2. Pfizer in 2. 01. 0. Kalamazoo was previously the world headquarters for the Upjohn Company. The deal cemented Pfizer's position as the largest pharmaceutical company in the world, with the merged company generating over US$2. AT& T and Bell. South's US$7. 0 billion deal in March 2. The acquisition was completed on October 1. Wyeth a wholly owned subsidiary of Pfizer. Harvard Business School's Gary Pisano told The Wall Street Journal, . There's just been an enormous amount of shareholder wealth destroyed. The medicine, called Bosulif, treats chronic myelogenous leukemia (CML), a blood and bone marrow disease that usually affects older adults. This deal expanded the company's vaccine portfolio targeting human cytomegalovirus. Pfizer is expected to receive an upfront sum of $2. Pfizer filed for registration of a Class A stock with the U. S. Securities and Exchange Commission on August 1. If successful, the takeover. As part of the deal, the Pfizer CEO, Ian Read, was to remain as CEO and chairman of the new company, to be called . As part of the deal, Allergan shareholders would receive 1. Pfizer shareholders receiving one. The terms proposed that the merged company would maintain Allergan's Irish domicile, resulting in the new company being subject to corporation tax at the Irish rate of 1. Pfizer paid at the time. Louis, Missouri. Sandwich, United Kingdom. Cambridge, United Kingdom. In 2. 00. 7, Pfizer announced plans to close or sell the Loughbeg API facility, located at Loughbeg, Ringaskiddy, Cork, Ireland by mid to end of 2. In 2. 00. 7, Pfizer announced plans to completely close the Ann Arbor, Nagoya and Amboise Research facilities by the end of 2. Michigan facility, which in recent years had seen expansion worth millions of dollars. The space will house Pfizer's Cardiovascular, Metabolic and Endocrine Disease Research Unit and its Neuroscience Research Unit; Pfizer anticipated moving into the space once it was completed in late 2. Lipitor was developed by Pfizer legacy company Warner- Lambert and first marketed in 1. From 1. 99. 6 to 2. Lipitor, atorvastatin became the world's best- selling drug of all time, with more than $1. The introduction of the original, 7- valent version of the vaccine in 1. United States. An improved version of the vaccine, providing coverage of 1. As of 2. 01. 2 the rate of invasive infections among children under age 5 has been reduced by an additional 5. Amlodipine is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. Fluconazole is recommended as a first- line treatment in invasive candidiasis. It is antibacterial against anaerobic organisms, an amoebicide, and an antiprotozoal. It was introduced to the market by Pfizer in 1. Sertraline is primarily prescribed for major depressive disorder in adult outpatients as well as obsessive. In 2. 01. 1, it was the second- most prescribed antidepressant on the U. S. Sales of Lyrica were $4. US patent on Lyrica was challenged by generic manufacturers and was upheld in 2. Pfizer exclusivity for Lyrica in the US until 2. In the US it does this through its Greenstone subsidiary, which it acquired as part of the acquisition of Pharmacia. Food and Drug Administration (FDA) approved gabapentin (Neurontin, Pfizer) only for treatment of seizures. Within 5 years the drug was being widely used for the off- label treatment of pain and psychiatric conditions. Food and Drug Administration (FDA) and caused false claims to be submitted to Federal and State programs. The criminal fine was the largest ever assessed in the United States up to that time. Pfizer had to also put a searchable database of all payments to physicians the company had made on the Pfizer website by March 3. During that time he raised concerns internally about kickbacks and off- label marketing of Genotropin, Pharmacia's human growth hormone drug. Pfizer reported the Pharmacia marketing practices to the FDA and Department of Justice; Rost was unaware of this and filed an FCA lawsuit against Pfizer. Pfizer kept him on, but isolated him until the FCA suit was unsealed in 2. The Justice Department declined to intervene, and Pfizer fired him, and he filed a wrongful termination suit against Pfizer. Wyeth is targeted in the suit for off- label marketing, targeting specific doctors and medical facilities to increase sales of Rapamune, trying to get current transplant patients to change from their current transplant drugs to Rapamune and for specifically targeting African- Americans. According to the whistleblowers, Wyeth also provided doctors and hospitals with kickbacks to prescribe the drug in the form of grants, donations and other money. By August 2. 01. 4 it had paid $4. New London case before the U. S. Supreme Court. The Supreme Court's 2. Kelo v. City of New London handed local governments the right to seize private property for economic development. 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